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Ions of TBI substance interactions into a network in this way correlates well with systems biology (and by extension, systems medicine), which is concerned with the complex network interplay of a biological unit and represents injury and illness as a perturbation to the network. Predications were extracted by SemRep and the component subject or object concepts were mapped to nodes and their relationships (predicates) mapped to edges, creating a network of relations. This network represents a summary of the physiological and pharmacogenomic space of neurological injury, as presented in the literature included in MEDLINE. To identify clinically significant candidates for mTBI biomarkers, the network was then filtered by degree centrality and frequency, greatly reducing the density of concepts and relationships. The resulting network produced 17 compounds to be considered as mTBI biomarkers, both previously investigated and novel as TBI biomarker candidates. The interaction of several of these is discussed as the basis for a panel of biomarkers to more effectively diagnose mTBI than is currently possible.Availability of data and softwareThe predication data (SemMedDB) is available at skr3.nlm.nih.gov. Degree and frequency filtering java programs are available at PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25751659 skr3.nlm.nih.gov/mTBI.Competing interests The authors declare that they have no competing interests. Authors' contributions MJC participated in the design of the study; performed the PubMed Searches; queried the SemMedDB database; participated in the graph creation, filtering, and visualization; and drafted the manuscript. MF participated in the design of the study and helped to draft the manuscript. HZ participated in the graph creation, filtering, and visualization and helped to draft the manuscript. TCR participated in the design of the study and helped to draft the manuscript. All authors read and approved the final manuscript. Acknowledgments This research was supported in part by an appointment to the National Library of Medicine Research Participation Program administered by the OakReferences 1. West TD, Marsh JO, Schwarz JJH, Bacchus J, Fisher A, Jumper JP, et al. Rebuilding the trust: report on rehabilitative care and administrative processes at Walter Reed Army Medical Center and National Naval Medical Center. Alexandria, VA; 2007. Nelfinavir (Mesylate) 2. Hart J, Kraut MA, Womack KB, Strain J, Didehbani N, Bartz E, et al. Neuroimaging of cognitive dysfunction and depression in aging retired national football league players: a cross-sectional study. JAMA Neurol. 2013;70(3):1?0. 3. Pellman EJ, Viano DC, National Football League's Committee on Mild Traumatic Brain Injury. Concussion in professional football: summary of the research conducted by the National Football League's Committee on Mild Traumatic Brain Injury. Neurosurg Focus. 2006;21(4):E12. 4. Jordan BD. Chronic traumatic brain injury associated with boxing. Semin Neurol. 2000;20(2):179?5. 5. Guskiewicz KM, McCrea M, Marshall SW, Cantu RC, Randolph C, Barr W, et al. Cumulative effects associated with recurrent concussion in collegiate football players: The NCAA Concussion Study. JAMA. 2003;290(19):2549?5. 6. Hollis SJ, Stevenson MR, McIntosh AS, Shores EA, Collins MW, Taylor CB. Incidence, risk, and protective factors of mild traumatic brain injury in a cohort of Australian nonprofessional male rugby players. Am J Sports Med. 2009;37(12):2328?3. 7. Biasca N, Maxwell WL. Minor traumatic brain injury in sports: a review in order to prevent.